Title: Influence of Developmental Nicotine Exposure on Spike Timing Precision & Reliability in Hypoglossal Motoneurons Abbreviated Title: Developmental Nicotine and Motoneuron Intrinsic Properties Author Names and Affiliations
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چکیده
Title: Influence of developmental nicotine exposure on spike timing precision & 1 reliability in hypoglossal motoneurons 2 3 Abbreviated title: developmental nicotine and motoneuron intrinsic properties 4 5 Author names and affiliations: 6 Gregory L. Powell, Richard B. Levine , Amanda M. Frazier, Ralph F. Fregosi 2 7 Departments of Physiology, Neuroscience and Biomedical Engineering, The 8 University of Arizona, Tucson, AZ, 85724 9 10 Corresponding author: 11 Ralph F. Fregosi 12 Dept. of Physiology 13 University of Arizona 14 Tucson, AZ 85724 15 [email protected] 16 520-621-2203 17 18 19 Articles in PresS. J Neurophysiol (December 30, 2014). doi:10.1152/jn.00838.2014
منابع مشابه
Influence of developmental nicotine exposure on spike-timing precision and reliability in hypoglossal motoneurons.
Smoothly graded muscle contractions depend in part on the precision and reliability of motoneuron action potential generation. Whether or not a motoneuron generates spikes precisely and reliably depends on both its intrinsic membrane properties and the nature of the synaptic input that it receives. Factors that perturb neuronal intrinsic properties and/or synaptic drive may compromise the tempo...
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Nicotine is a drug of abuse that has been reported to have many adverse effects on the developing nervous system. We previously demonstrated that embryonic exposure to nicotine alters axonal pathfinding of spinal secondary motoneurons in zebrafish. We hypothesize that these changes will persist into adulthood. The Tg(isl1:GFP) line of zebrafish, which expresses green fluorescent protein (GFP) i...
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تاریخ انتشار 2014